| Pair Name | Artesunate, Metformin | ||
| Phytochemical Name | Artesunate (PubChem CID: 6917864 ) | ||
| Anticancer drug Name | Metformin (PubChem CID: 4091 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Artesunate, Metformin | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | CASP9 | hsa842 |
| Down-regulation | Expression | MAP1LC3A | hsa84557 | |
| Up-regulation | Expression | MAP1LC3B | hsa81631 | |
| Down-regulation | Phosphorylation | MTOR | hsa2475 | |
| Up-regulation | Phosphorylation | PRKAA1 | hsa5562 | |
| Down-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | U-118MG | Astrocytoma | Homo sapiens (Human) | CVCL_0633 |
| U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 | |
| Result | The study findings suggest that MET used in combination with ART can induce autophagy-dependent apoptosis in GBM cells by activating the ROS-AMPK-mTOR pathway, providing a potential new treatment for GBM. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis. Exp Cell Res. 2023 Sep 1;430(1):113691. doi: 10.1016/j.yexcr.2023.113691. | Click |
